RARE GENE GLITCH MAY HOLD CLUES FOR SCHIZOPHRENIA – NIH-FUNDED STUDY: A NORTH STAR AMID “A CONSTELLATION OF MULTIPLE RARE DISEASES”

Scientists are eyeing a rare genetic glitch for clues to improved treatments for some people with schizophrenia — even though they found the mutation in only one-third of one percent of study participants. In the study, funded in part by the National Institutes of Health (NIH), people with schizophrenia were 14 times more likely than people without schizophrenia to harbor multiple copies of a gene on Chromosome 7. The mutations were in the gene for VIPR2, the receptor for vasoactive intestinal peptide (VIP) — a chemical messenger known to play a role in brain development. An examination of participants’ blood confirmed that they had overactive VIP activity.

Press release: http://www.nimh.nih.gov/science-news/2011/rare-gene-glitch-may-hold-clues-for-schizophrenia-nih-funded-study.shtml

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